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| http://purl.uniprot.org/citations/11588141 | http://www.w3.org/2000/01/rdf-schema#comment | "Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by intrapancreatic nerve endings during the preabsorptive and absorptive phases of feeding. In beta-cells, ACh binds to muscarinic M(3) receptors and exerts complex effects, which culminate in an increase of glucose (nutrient)-induced insulin secretion. Activation of PLC generates diacylglycerol. Activation of PLA(2) produces arachidonic acid and lysophosphatidylcholine. These phospholipid-derived messengers, particularly diacylglycerol, activate PKC, thereby increasing the efficiency of free cytosolic Ca(2+) concentration ([Ca(2+)](c)) on exocytosis of insulin granules. IP3, also produced by PLC, causes a rapid elevation of [Ca(2+)](c) by mobilizing Ca(2+) from the endoplasmic reticulum; the resulting fall in Ca(2+) in the organelle produces a small capacitative Ca(2+) entry. ACh also depolarizes the plasma membrane of beta-cells by a Na(+)-dependent mechanism. When the plasma membrane is already depolarized by secretagogues such as glucose, this additional depolarization induces a sustained increase in [Ca(2+)](c). Surprisingly, ACh can also inhibit voltage-dependent Ca(2+) channels and stimulate Ca(2+) efflux when [Ca(2+)](c) is elevated. However, under physiological conditions, the net effect of ACh on [Ca(2+)](c) is always positive. The insulinotropic effect of ACh results from two mechanisms: one involves a rise in [Ca(2+)](c) and the other involves a marked, PKC-mediated increase in the efficiency of Ca(2+) on exocytosis. The paper also discusses the mechanisms explaining the glucose dependence of the effects of ACh on insulin release."xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.org/dc/terms/identifier | "doi:10.1210/edrv.22.5.0440"xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/author | "Gilon P."xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/author | "Henquin J.C."xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/name | "Endocr Rev"xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/pages | "565-604"xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/title | "Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function."xsd:string |
| http://purl.uniprot.org/citations/11588141 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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