| http://purl.uniprot.org/citations/11588176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11588176 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterotetrameric adaptor complexes vesiculate donor membranes. One of the adaptor protein complexes, AP-3, is present in two forms; one form is expressed in all tissues of the body, whereas the other is restricted to brain. Mice lacking both the ubiquitous and neuronal forms of AP-3 exhibit neurological disorders that are not observed in mice that are mutant only in the ubiquitous form. To begin to understand the role of neuronal AP-3 in neurological disease, we investigated its function in in vitro assays as well as its localization in neural tissue. In the presence of GTPgammaS both ubiquitous and neuronal forms of AP-3 can bind to purified synaptic vesicles. However, only the neuronal form of AP-3 can produce synaptic vesicles from endosomes in vitro. We also identified that the expression of neuronal AP-3 is limited to varicosities of neuronal-like processes and is expressed in most axons of the brain. Although the AP-2/clathrin pathway is the major route of vesicle production and the relatively minor neuronal AP-3 pathway is not necessary for viability, the absence of the latter could lead to the neurological abnormalities seen in mice lacking the expression of AP-3 in brain. In this study we have identified the first brain-specific function for a neuronal adaptor complex."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.21-20-08034.2001"xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/author | "Nakatsu F."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/author | "Kelly R.B."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/author | "Blumstein J."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/pages | "8034-8042"xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/title | "The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes."xsd:string |
| http://purl.uniprot.org/citations/11588176 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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