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http://purl.uniprot.org/citations/11592043http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11592043http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the correlation between type 1 diabetes mellitus susceptibility and HLA-DPB1 and DQB1 genes in Shandong Han population.

Methods

HLA-DPB1 and DQB1 genes analysis were performed by sequencing-based typing in 52 type 1 diabetes mellitus patients and 38 normal controls.

Results

The frequency of DPB1*2201 in diabetics was significantly higher than that in controls(26.92% vs 5.26%, P<0.01), but the frequency of DPB1*0402 in diabetics was significantly lower than that in controls(11.54% vs 34.21%, P<0.01). The frequencies of DQB1*0201, *0303 and *0604 in diabetics were higher than those in controls (24.04% vs 10.53%, P< 0.01; 22.12% vs 6.58%, P<0.05; 19.23% vs 7.89%, P<0.05), while the frequency of DQB1*0301 in diabetics was significantly lower than that in controls (4.81% vs 25.00%, P<0.01).

Conclusion

DPB1*2201, DQB1*0201, *0303 and *0604 may be susceptible alleles, and DPB1*0402 and DQB1*0301 may be protective alleles in patients with type 1 diabetes mellitus."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/author"Zhang S."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/author"Yan H."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/author"Xing W."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/author"Jiang Z."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/author"Ke B."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/pages"362-365"xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/title"[Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus]."xsd:string
http://purl.uniprot.org/citations/11592043http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/11592043http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11592043
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