| http://purl.uniprot.org/citations/11595183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11595183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11595183 | http://www.w3.org/2000/01/rdf-schema#comment | "The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII, dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Here, we describe an additional member of this signaling pathway, ced-12, and its mammalian homologs, elmo1 and elmo2. In C. elegans, CED-12 is required for engulfment of dying cells and for cell migrations. In mammalian cells, ELMO1 functionally cooperates with CrkII and Dock180 to promote phagocytosis and cell shape changes. CED-12/ELMO-1 binds directly to CED-5/Dock180; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements. These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00520-7"xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00520-7"xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Hengartner M.O."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Hengartner M.O."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Van Aelst L."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Van Aelst L."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Haney L.B."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Haney L.B."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Kinchen J.M."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Kinchen J.M."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Tosello-Trampont A.-C."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Tosello-Trampont A.-C."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Francis R."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Francis R."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Nishiwaki K."xsd:string |
| http://purl.uniprot.org/citations/11595183 | http://purl.uniprot.org/core/author | "Nishiwaki K."xsd:string |