| http://purl.uniprot.org/citations/11598033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11598033 | http://www.w3.org/2000/01/rdf-schema#comment | "We showed recently that activation of Valpha14(+) natural killer T cells (NKT cells) by alpha-galactosylceramide (alpha-GalCer) resulted in increased gamma interferon (IFN-gamma) production and host resistance to intravenous infection with Cryptococcus neoformans. In other studies, interleukin-18 (IL-18) activated NKT cells in collaboration with IL-12, suggesting the possible contribution of this cytokine to alpha-GalCer-induced IFN-gamma synthesis. Here we examined the role of IL-18 in alpha-GalCer-induced Th1 response by using IL-18KO mice with this infection. In these mice, levels of IFN-gamma in serum and its synthesis in vitro by spleen cells stimulated with live organisms were not reduced, but rather enhanced, compared to those in wild-type (WT) mice, while such production was completely absent in IL-12KO mice. The enhanced production of IFN-gamma correlated with increased IL-12 synthesis but not with reduced production of IL-4, which was rather increased. IFN-gamma synthesis in IL-18KO mice was abolished by neutralizing anti-IL-12 antibody and significantly inhibited by neutralization of endogenous IL-4 with a specific monoclonal antibody. In addition, administration of recombinant IL-4 significantly enhanced the production of IFN-gamma in WT mice. Finally, the enhanced production of IFN-gamma in IL-18KO mice correlated with increased host defense against cryptococcal infection, as indicated by enhancement in alpha-GalCer-related clearance of microorganisms. Our results indicated that in IL-18KO mice, IFN-gamma synthesis was enhanced through overproduction of IL-12 and IL-4 after intravenous infection with C. neoformans and a ligand-specific activation of Valpha14(+) NKT cells."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.69.11.6643-6650.2001"xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Saito A."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Tohyama M."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Koguchi Y."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Kinjo Y."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Yara S."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/author | "Uezu K."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/pages | "6643-6650"xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/title | "Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis."xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/11598033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11598033 |
| http://purl.uniprot.org/citations/11598033 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11598033 |
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| http://purl.uniprot.org/uniprot/#_A0PJ18-mappedCitation-11598033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11598033 |
| http://purl.uniprot.org/uniprot/#_P70380-mappedCitation-11598033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11598033 |
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| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-11598033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11598033 |