| http://purl.uniprot.org/citations/11598150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11598150 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and in synovial tissues from patients with rheumatoid arthritis (RA). To determine the participation of IL-18 in the inflammation observed in RA, we investigated the effect of IL-18 on RA synovial fibroblast chemokine production. Using FACS analysis, we showed that IL-18 induced a doubling in the production of intracellular IL-8 by RA synovial fibroblasts, and this result was confirmed by Western blot. At the extracellular level, IL-18 up-regulated the secretion of IL-8 in a dose- and time-dependent manner. IL-18 also up-regulated the other CXC chemokines, epithelial-neutrophil activating protein (ENA-78) and growth-regulated oncogene (groalpha), in a dose dependent manner, but failed to induce the production of the CC chemokine, macrophage inflammatory protein (MIP)-1alpha. By immunofluorescence and Western blot, we demonstrated that IL-18 activates the translocation of the transcription factor nuclear factor kappa B (NFkappaB) into the nucleus of RA synovial fibroblasts. IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide. These results indicate a novel role for IL-18 in inducing RA synovial fibroblast expression of CXC chemokines through NFkappaB and place this cytokine in a strategic role in the local inflammation observed in RA."xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.org/dc/terms/identifier | "doi:10.1038/labinvest.3780351"xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/author | "Kumar P."xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/author | "Koch A.E."xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/author | "Morel J.C."xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/author | "Park C.C."xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/name | "Lab Invest"xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/pages | "1371-1383"xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/title | "Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation."xsd:string |
| http://purl.uniprot.org/citations/11598150 | http://purl.uniprot.org/core/volume | "81"xsd:string |
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