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http://purl.uniprot.org/citations/11600844http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11600844http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11600844http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11600844http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To describe the genetic diversity of HIV-1 in South America by full genome sequencing and analysis.

Methods

Purified peripheral blood mononuclear cell DNA from HIV-infected individuals in Argentina, Uruguay and Bolivia was used to amplify full HIV-1 genomes. These were sequenced using the ABI 3100 automated sequencer and phylogenetically analysed.

Results

Twenty-one HIV-1 strains from three South American countries, 17 of which were pre-screened by envelope heteroduplex mobility assay (HMA), were studied. Ten out of 10 HMA subtype F and four out of seven HMA subtype B strains were actually BF recombinants upon full genome analysis. Two BF recombinants from Argentina and two from Uruguay had the same structure, representing a new circulating recombinant form termed CRF12_BF(ARMA159). Twelve other BF recombinants had structures related to CRF12 but with additional segments of subtype B; each was unique. BF recombinants were temporally and geographically widespread, found as early as 1986-1987 in vertically infected Argentinian children and in Argentina, Uruguay, and Bolivia."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.org/dc/terms/identifier"doi:10.1097/00002030-200110190-00002"xsd:string
http://purl.uniprot.org/citations/11600844http://purl.org/dc/terms/identifier"doi:10.1097/00002030-200110190-00002"xsd:string
http://purl.uniprot.org/citations/11600844http://purl.org/dc/terms/identifier"doi:10.1097/00002030-200110190-00002"xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Carr J.K."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Carr J.K."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Carr J.K."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"McCutchan F.E."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"McCutchan F.E."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"McCutchan F.E."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Russell K.L."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Russell K.L."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Russell K.L."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Birx D.L."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Birx D.L."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Birx D.L."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Sanchez J."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Sanchez J."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Sanchez J."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Andrade R."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Andrade R."xsd:string
http://purl.uniprot.org/citations/11600844http://purl.uniprot.org/core/author"Andrade R."xsd:string
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