http://purl.uniprot.org/citations/11602646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11602646 | http://www.w3.org/2000/01/rdf-schema#comment | "Given the broad expression of H-2 class Ib molecules on hematopoietic cells, antigen presentation pathways among CD1d expressing cells might tightly regulate CD1d-restricted natural killer T (NKT) cells. Bone marrow-derived dendritic cells (BM-DCs) and not adherent splenocytes become capable of triggering NK1.1(+)/T cell receptor (TCR)(int) hepatic NKT cell activation when (a) immature BM-DCs lack H-2D(b)-/-molecules or (b) BM-DCs undergo a stress signal of activation. In such conditions, BM-DCs promote T helper type 1 predominant CD1d-restricted NKT cell stimulation. H-2 class Ia-mediated inhibition involves more the direct H-2D(b) presentation than the indirect Qa-1(b) pathway. Such inhibition can be overruled by B7/CD28 interactions and marginally by CD40/CD40L or interleukin 12. These data point to a unique regulatory role of DCs in NKT cell innate immune responses and suggest that H-2 class Ia and Ib pathways differentially control NKT cell recognition of DC antigens."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.194.8.1179"xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Bendelac A."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Tursz T."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Wakasugi H."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Terada M."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Zitvogel L."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Ikarashi Y."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Mikami R."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Angevin E."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Chaput N."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/author | "Terme M."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/pages | "1179-1186"xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/title | "Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon gamma production."xsd:string |
http://purl.uniprot.org/citations/11602646 | http://purl.uniprot.org/core/volume | "194"xsd:string |
http://purl.uniprot.org/citations/11602646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11602646 |
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