| http://purl.uniprot.org/citations/11668495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11668495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11668495 | http://www.w3.org/2000/01/rdf-schema#comment | "TENB2 encodes a putative transmembrane proteoglycan, related to the EGF/heregulin family of growth factors and follistatin, which has been identified through the application of a differential display technique to a xenograft model of prostate cancer. Northern analysis and competitive PCR were used to demonstrate significantly increased TENB2 expression (p = 0.0003) on the acquisition of androgen independence in the model system. TENB2 is also overexpressed in clinical prostate carcinoma vs. its benign counterpart (p < 0.0001), with particular prominence in high-grade tumours, and shows a high degree of tissue specificity, being detected on a multitissue Northern array exclusively in brain and prostate material. Studies of recombinant protein expression demonstrate that TENB2 is a chondroitin sulphate proteoglycan. The presence of an EGF and 2 follistatin domains suggests a role in the regulation of growth factor signalling either as a ligand precursor, a membrane-bound receptor or as a binding protein for growth factors. These data are indicative of a significant role for TENB2 in the progression of poorly differentiated tumour types, with implications for prostate cancer detection, prognosis and therapy."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.1450"xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.1450"xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "James R."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "James R."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Harper M.E."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Harper M.E."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Taylor K.M."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Taylor K.M."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Gee J.M."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Gee J.M."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Seery L.T."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Seery L.T."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Morgan H.E."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Morgan H.E."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Nicholson R.I."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Nicholson R.I."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Anglin I."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Anglin I."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Glynne-Jones E."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/author | "Glynne-Jones E."xsd:string |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11668495 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |