| http://purl.uniprot.org/citations/11675505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11675505 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the N-methyl-d-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in the central nervous system. NMDARs are phosphorylated by both serine/threonine and tyrosine kinases. Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at Ser-1232 in vitro and in intact cells. Moreover, we show that roscovitine, a selective Cdk5 inhibitor, blocks both long-term potentiation induction and NMDA-evoked currents in rat CA1 hippocampal neurons. These results suggest that Cdk5 plays a key role in synaptic transmission and plasticity through its up-regulation of NMDARs."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.211428098"xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Brady R.O."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Kulkarni A.B."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Pant H.C."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Vinade L."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Li B.S."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/author | "Sun M.K."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/pages | "12742-12747"xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/title | "Regulation of NMDA receptors by cyclin-dependent kinase-5."xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/11675505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11675505 |
| http://purl.uniprot.org/citations/11675505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11675505 |
| http://purl.uniprot.org/uniprot/#_A0A8L2UIH0-mappedCitation-11675505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11675505 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y6S3-mappedCitation-11675505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11675505 |
| http://purl.uniprot.org/uniprot/#_Q03114-mappedCitation-11675505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11675505 |
| http://purl.uniprot.org/uniprot/#_Q00959-mappedCitation-11675505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11675505 |
| http://purl.uniprot.org/uniprot/A0A8L2UIH0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11675505 |
| http://purl.uniprot.org/uniprot/Q00959 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11675505 |