| http://purl.uniprot.org/citations/11679632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11679632 | http://www.w3.org/2000/01/rdf-schema#comment | "ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its ligand heregulin (HRG) or activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA), the ErbB-4 ectodomain is cleaved by a metalloprotease. We now report a subsequent cleavage by gamma-secretase that releases the ErbB-4 intracellular domain from the membrane and facilitates its translocation to the nucleus. gamma-Secretase cleavage was prevented by chemical inhibitors or a dominant negative presenilin. Inhibition of gamma-secretase also prevented growth inhibition by HRG. gamma-Secretase cleavage of ErbB-4 may represent another mechanism for receptor tyrosine kinase-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1065412"xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/author | "Carpenter G."xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/author | "Murphy M.P."xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/author | "Golde T.E."xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/author | "Ni C.Y."xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/pages | "2179-2181"xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/title | "gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/11679632 | http://purl.uniprot.org/core/volume | "294"xsd:string |
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