| http://purl.uniprot.org/citations/11687612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11687612 | http://www.w3.org/2000/01/rdf-schema#comment | "The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between single-nucleotide polymorphisms in the aldosterone synthase gene and plasma glucose levels in a large population of Chinese and Japanese origin. Two polymorphisms--one in the putative promoter (T-344C) and another resulting in a lysine/arginine substitution at amino acid 173, which are in complete linkage disequilibrium in this population--were associated with fasting plasma glucose levels (P = 0.000017) and those 60 (P = 0.017) and 120 (P = 0.0019) min after an oral glucose challenge. A C/T variant in intron 1, between these polymorphisms, was not associated with glucose levels. Arg-173 and -344C homozygotes were most likely to be diabetic [odds ratio 2.51; 95% confidence interval (C.I.) 1.39-3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C.I. 2.02-5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.221467098"xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Cox D.R."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Pei D."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Botstein D."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Lin A."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Curb D."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Jorgenson E."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Olshen R.A."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Ranade K."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Risch N."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Chuang L.M."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Chen Y.D."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Olivier M."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Wu K.D."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Ho L.T."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Dzau V."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Pesich R."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/author | "Hsiao C.F."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/pages | "13219-13224"xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/title | "Genetic variation in aldosterone synthase predicts plasma glucose levels."xsd:string |
| http://purl.uniprot.org/citations/11687612 | http://purl.uniprot.org/core/volume | "98"xsd:string |