| http://purl.uniprot.org/citations/11689445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11689445 | http://www.w3.org/2000/01/rdf-schema#comment | "The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells. Experiments with Src, p85alpha and Akt dominant-negative forms indicate that in oestradiol-treated cells these signalling effectors target the cyclin D1 promoter. Oestradiol acutely increases PI3-kinase and Akt activities in MCF-7 cells. In NIH 3T3 cells expressing ERalpha, a dominant-negative p85 suppresses hormone stimulation of Akt. The Src inhibitor, PP1, prevents hormone stimulation of Akt and PI3-kinase activities in MCF-7 cells. In turn, stimulation of Src activity is abolished in ERalpha-expressing NIH 3T3 fibroblasts by co-transfection of the dominant-negative p85alpha and in MCF-7 cells by the PI3-kinase inhibitor, LY294002. These findings indicate a novel reciprocal cross-talk between PI3-kinase and Src. Hormone stimulation of MCF-7 cells rapidly triggers association of ERalpha with Src and p85. In vitro these proteins are assembled in a ternary complex with a stronger association than that of the binary complexes composed by the same partners. The ternary complex probably favours hormone activation of Src- and PI3-kinase-dependent pathways, which converge on cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.21.6050"xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Lombardi M."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Di Domenico M."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Barone M.V."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Auricchio F."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Bilancio A."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Castoria G."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Migliaccio A."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Varricchio L."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "de Falco A."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/author | "Fiorentino R."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/pages | "6050-6059"xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/title | "PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells."xsd:string |
| http://purl.uniprot.org/citations/11689445 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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