| http://purl.uniprot.org/citations/11696000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11696000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11696000 | http://www.w3.org/2000/01/rdf-schema#comment | "We hypothesized that certain proteins encoded by temperature-responsive genes in brown adipose tissue (BAT) contribute to the remarkable metabolic shifts observed in this tissue, thus prompting a differential mRNA expression analysis to identify candidates involved in this process in mouse BAT. An mRNA species corresponding to a novel partial-length gene was found to be induced 2-3-fold above the control following cold exposure (4 degrees C), and repressed approximately 70% by warm acclimation (33 degrees C, 3 weeks) compared with controls (22 degrees C). The gene displayed robust BAT expression (i.e. approximately 7-100-fold higher than other tissues in controls). The full-length murine gene encodes a 594 amino acid ( approximately 67 kDa) open reading frame with significant homology to the human hypothetical acyl-CoA thioesterase KIAA0707. Based on cold-inducibility of the gene and the presence of two acyl-CoA thioesterase domains, we termed the protein brown-fat-inducible thioesterase (BFIT). Subsequent analyses and cloning efforts revealed the presence of a novel splice variant in humans (termed hBFIT2), encoding the orthologue to the murine BAT gene. BFIT was mapped to syntenic regions of chromosomes 1 (human) and 4 (mouse) associated with body fatness and diet-induced obesity, potentially linking a deficit of BFIT activity with exacerbation of these traits. Consistent with this notion, BFIT mRNA was significantly higher ( approximately 1.6-2-fold) in the BAT of obesity-resistant compared with obesity-prone mice fed a high-fat diet, and was 2.5-fold higher in controls compared with ob/ob mice. Its strong, cold-inducible BAT expression in mice suggests that BFIT supports the transition of this tissue towards increased metabolic activity, probably through alteration of intracellular fatty acyl-CoA concentration."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3600135"xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3600135"xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Chui C."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Chui C."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Dowd P."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Dowd P."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Goddard A.D."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Goddard A.D."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Adams S.H."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Adams S.H."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Colman S."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Colman S."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Grimaldi J.C."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Grimaldi J.C."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Lewin D.A."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Lewin D.A."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Schilbach S.L."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Schilbach S.L."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Yu X.X."xsd:string |
| http://purl.uniprot.org/citations/11696000 | http://purl.uniprot.org/core/author | "Yu X.X."xsd:string |