| http://purl.uniprot.org/citations/11696533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11696533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11696533 | http://www.w3.org/2000/01/rdf-schema#comment | "The epithelial Na+ channel (ENaC) forms the pathway for Na+ absorption across epithelia, including the kidney collecting duct, where it plays a critical role in Na+ homeostasis and blood pressure control. Na+ absorption is regulated in part by mechanisms that control the expression of ENaC at the apical cell surface. Nedd4 family members (e.g. Nedd4, Nedd4-2) bind to the channel and decrease its surface expression by catalyzing its ubiquitination and degradation. Conversely, serum and glucocorticoid-regulated kinase (SGK), a downstream mediator of aldosterone, increases the expression of ENaC at the cell surface. Here we show that SGK and human Nedd4-2 (hNedd4-2) converge in a common pathway to regulate epithelial Na+ absorption. Consistent with this model, we found that SGK bound to hNedd4-2 and hNedd4. A PY motif in SGK mediated the interaction and was required for SGK to stimulate ENaC. SGK phosphorylated hNedd4-2 (but not hNedd4), altering hNedd4-2 function; phosphorylation reduced the binding of hNedd4-2 to alphaENaC, and hence, the hNedd4-2-mediated inhibition of Na+ absorption. These data suggest that SGK regulates epithelial Na+ absorption in part by modulating the function of hNedd4-2."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100623200"xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100623200"xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/author | "Thomas B.C."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/author | "Thomas B.C."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/author | "Snyder P.M."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/author | "Snyder P.M."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/author | "Olson D.R."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/author | "Olson D.R."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/pages | "5-8"xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/pages | "5-8"xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/title | "Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/title | "Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel."xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11696533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11696533 |
| http://purl.uniprot.org/citations/11696533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11696533 |
| http://purl.uniprot.org/citations/11696533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11696533 |
| http://purl.uniprot.org/citations/11696533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11696533 |