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| http://purl.uniprot.org/citations/11696543 | http://www.w3.org/2000/01/rdf-schema#comment | "Stabilization of insulin mRNA in response to glucose is a significant component of insulin production, but the mechanisms governing this process are unknown. We presently observe that insulin mRNA is a highly abundant messenger and that the content of this mRNA is mainly controlled by changes in messenger stability. We also demonstrate specific binding of the polypyrimidine tract-binding protein to a pyrimidine-rich sequence located in the 3'-untranslated region (3'-UTR) of insulin mRNA. This binding was increased in vitro by dithiothreitol and in vivo by glucose. Inhibition of polypyrimidine tract-binding protein binding to the pyrimidine-rich sequence by mutation of the core binding site resulted in a destabilization of a reporter gene mRNA. Thus, glucose-induced binding of polypyrimidine tract-binding protein to the 3'-UTR of insulin mRNA could be a necessary event in the control of insulin mRNA levels."xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108340200"xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/author | "Welsh N."xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/author | "Carlsson C."xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/author | "Tillmar L."xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/pages | "1099-1106"xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/title | "Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence."xsd:string |
| http://purl.uniprot.org/citations/11696543 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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