| http://purl.uniprot.org/citations/11698418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11698418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11698418 | http://www.w3.org/2000/01/rdf-schema#comment | "Some CD2 family receptors stimulate NK cell-mediated cytotoxicity through a signaling pathway, which is dependent on the recruitment of an adapter protein called SLAM-associated protein (SAP). In this work we identify a novel leukocyte cell surface receptor of the CD2 family called CD2-like receptor activating cytotoxic cells (CRACC). CRACC is expressed on cytotoxic lymphocytes, activated B cells, and mature dendritic cells, and activates NK cell-mediated cytotoxicity. Remarkably, although CRACC displays cytoplasmic motifs similar to those recruiting SAP, CRACC-mediated cytotoxicity occurs in the absence of SAP and requires activation of extracellular signal-regulated kinases-1/2. Thus, CRACC is a unique CD2-like receptor which mediates NK cell activation through a SAP-independent extracellular signal-regulated kinase-mediated pathway."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.10.5517"xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.10.5517"xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Cohen J.I."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Cohen J.I."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Bouchon A."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Bouchon A."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Grierson H.L."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/author | "Grierson H.L."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/pages | "5517-5521"xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/pages | "5517-5521"xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/title | "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/title | "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family."xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/11698418 | http://purl.uniprot.org/core/volume | "167"xsd:string |