| http://purl.uniprot.org/citations/11698470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11698470 | http://www.w3.org/2000/01/rdf-schema#comment | "Malaria, caused by infection with Plasmodium spp., is a life cycle-specific disease that includes liver injury at the erythrocyte stage of the parasite. In this study, we have investigated the mechanisms underlying Plasmodium berghei-induced liver injury, which is characterized by the presence of apoptotic and necrotic hepatocytes and dense infiltration of lymphocytes. Although both IL-12 and IL-18 serum levels were elevated after infection, IL-12-deficient, but not IL-18-deficient, mice were resistant to liver injury induced by P. berghei. Neither elevation of serum IL-12 levels nor liver injury was observed in mice deficient in myeloid differentiation factor 88 (MyD88), an adaptor molecule shared by Toll-like receptors (TLRs). These results demonstrated a requirement of the TLR-MyD88 pathway for induction of IL-12 production during P. berghei infection. Hepatic lymphocytes from P. berghei-infected wild-type mice lysed hepatocytes from both uninfected and infected mice. The hepatocytotoxic action of these cells was blocked by a perforin inhibitor but not by a neutralizing anti-Fas ligand Ab and was up-regulated by IL-12. Surprisingly, these cells killed hepatocytes in an MHC-unrestricted manner. However, CD1d-deficient mice that lack CD1d-restricted NK T cells, were susceptible to liver injury induced by P. berghei. Collectively, our results indicate that the liver injury induced by P. berghei infection of mice induces activation of the TLR-MyD88 signaling pathway which results in IL-12 production and activation of the perforin-dependent cytotoxic activities of MHC-unrestricted hepatic lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.10.5928"xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Nakano H."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Adachi K."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Nakanishi K."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Tsutsui H."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Okamura H."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Seki E."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Kashiwamura S."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/pages | "5928-5934"xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/title | "Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/11698470 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11698470 |
| http://purl.uniprot.org/citations/11698470 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11698470 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTV4-mappedCitation-11698470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11698470 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STF5-mappedCitation-11698470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11698470 |
| http://purl.uniprot.org/uniprot/#_Q0PM14-mappedCitation-11698470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11698470 |