| http://purl.uniprot.org/citations/11700562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11700562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11700562 | http://www.w3.org/2000/01/rdf-schema#comment | "The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a systemic infection. Two components of the toxin enzymatically modify substrates within the cytosol of mammalian cells: oedema factor (OF) is an adenylate cyclase that impairs host defences through a variety of mechanisms including inhibiting phagocytosis; lethal factor (LF) is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinase and causes lysis of macrophages. Protective antigen (PA), the third component, binds to a cellular receptor and mediates delivery of the enzymatic components to the cytosol. Here we describe the cloning of the human PA receptor using a genetic complementation approach. The receptor, termed ATR (anthrax toxin receptor), is a type I membrane protein with an extracellular von Willebrand factor A domain that binds directly to PA. In addition, a soluble version of this domain can protect cells from the action of the toxin."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.org/dc/terms/identifier | "doi:10.1038/n35101999"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.org/dc/terms/identifier | "doi:10.1038/n35101999"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Collier R.J."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Collier R.J."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Mourez M."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Mourez M."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Bradley K.A."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Bradley K.A."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Mogridge J."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Mogridge J."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Young J.A.T."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/author | "Young J.A.T."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/pages | "225-229"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/pages | "225-229"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/title | "Identification of the cellular receptor for anthrax toxin."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/title | "Identification of the cellular receptor for anthrax toxin."xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/volume | "414"xsd:string |
| http://purl.uniprot.org/citations/11700562 | http://purl.uniprot.org/core/volume | "414"xsd:string |