| http://purl.uniprot.org/citations/11701890 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11701890 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11701890 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe a molecular switch based on the controlled methylation of nucleosome and the transcriptional cofactors, the CREB-binding proteins (CBP)/p300. The CBP/p300 methylation site is localized to an arginine residue that is essential for stabilizing the structure of the KIX domain, which mediates CREB recruitment. Methylation of KIX by coactivator-associated arginine methyltransferase 1 (CARM1) blocks CREB activation by disabling the interaction between KIX and the kinase inducible domain (KID) of CREB. Thus, CARM1 functions as a corepressor in cyclic adenosine monophosphate signaling pathway via its methyltransferase activity while acting as a coactivator for nuclear hormones. These results provide strong in vivo and in vitro evidence that histone methylation plays a key role in hormone-induced gene activation and define cofactor methylation as a new regulatory mechanism in hormone signaling."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1065961"xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1065961"xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Montminy M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Montminy M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Du K."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Du K."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Emerson B.M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Emerson B.M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Asahara H."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Asahara H."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Tini M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/author | "Tini M."xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11701890 | http://purl.uniprot.org/core/name | "Science"xsd:string |