| http://purl.uniprot.org/citations/11702237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11702237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11702237 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have shown the implication of beta-defensins in host defense of the human body. The human beta-defensins 1 and 2 (hBD-1, hBD-2) have been isolated by biochemical methods. Here we report the identification of a third human beta-defensin, called human beta-defensin 3 (hBD-3; cDNA sequence, Genbank accession no. AF295370), based on bioinformatics and functional genomic analysis. Expression of hBD-3 is detected throughout epithelia of many organs and in non-epithelial tissues. In contrast to hBD-2, which is upregulated by microorganisms or tumor necrosis factor-alpha (TNF-alpha), hBD-3 expression is increased particularly after stimulation by interferon-gamma. Synthetic hBD-3 exhibits a strong antimicrobial activity against gram-negative and gram-positive bacteria and fungi, including Burkholderia cepacia. In addition, hBD-3 activates monocytes and elicits ion channel activity in biomembranes, specifically in oocytes of Xenopus laevis. This paper also shows that screening of genomic sequences is a valuable tool with which to identify novel regulatory peptides. Human beta-defensins represent a family of antimicrobial peptides differentially expressed in most tissues, regulated by specific mechanisms, and exerting physiological functions not only related to direct host defense."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.org/dc/terms/identifier | "doi:10.1007/s004410100433"xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.org/dc/terms/identifier | "doi:10.1007/s004410100433"xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Becker D."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Becker D."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Hedrich R."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Hedrich R."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Krause A."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Krause A."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Schulz S."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Schulz S."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Vogelmeier C."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Vogelmeier C."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Forssmann W.-G."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Forssmann W.-G."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Adermann K."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Adermann K."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Bals R."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Bals R."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Forssmann U."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Forssmann U."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Conejo-Garcia J.-R."xsd:string |
| http://purl.uniprot.org/citations/11702237 | http://purl.uniprot.org/core/author | "Conejo-Garcia J.-R."xsd:string |