| http://purl.uniprot.org/citations/11703925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11703925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11703925 | http://www.w3.org/2000/01/rdf-schema#comment | "RIN1 was originally identified by its ability to inhibit activated Ras and likely participates in multiple signaling pathways because it binds c-ABL and 14-3-3 proteins, in addition to Ras. RIN1 also contains a region homologous to the catalytic domain of Vps9p-like Rab guanine nucleotide exchange factors (GEFs). Here, we show that this region is necessary and sufficient for RIN1 interaction with the GDP-bound Rabs, Vps21p, and Rab5A. RIN1 is also shown to stimulate Rab5 guanine nucleotide exchange, Rab5A-dependent endosome fusion, and EGF receptor-mediated endocytosis. The stimulatory effect of RIN1 on all three of these processes is potentiated by activated Ras. We conclude that Ras-activated endocytosis is facilitated, in part, by the ability of Ras to directly regulate the Rab5 nucleotide exchange activity of RIN1."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(01)00008-9"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(01)00008-9"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Stahl P.D."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Stahl P.D."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Horazdovsky B.F."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Horazdovsky B.F."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Tall G.G."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Tall G.G."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Barbieri M.A."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/author | "Barbieri M.A."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/pages | "73-82"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/pages | "73-82"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/title | "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/title | "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1."xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/11703925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11703925 |
| http://purl.uniprot.org/citations/11703925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11703925 |