| http://purl.uniprot.org/citations/11703939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11703939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11703939 | http://www.w3.org/2000/01/rdf-schema#comment | "The C. elegans gene ced-12 functions in the engulfment of apoptotic cells and in cell migration, acting in a signaling pathway with ced-2 Crkll, ced-5 DOCK180, and ced-10 Rac GTPase and acting upstream of ced-10 Rac. ced-12 encodes a protein with a pleckstrin homology (PH) domain and an SH3 binding motif, both of which are important for ced-12 function. CED-12 acts in engulfing cells for cell corpse engulfment and interacts physically with CED-5, which contains an SH3 domain. CED-12 has Drosophila and human counterparts. Expression of CED-12 and its counterparts in murine Swiss 3T3 fibroblasts induced Rho GTPase-dependent formation of actin filament bundles. We propose that through interactions with membranes and with a CED-2/CED-5 protein complex, CED-12 regulates Rho/Rac GTPase signaling and leads to cytoskeletal reorganization by an evolutionarily conserved mechanism."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(01)00058-2"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(01)00058-2"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.org/dc/terms/identifier | "doi:10.1016/S1534-5807(01)00058-2"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Hall A."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Hall A."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Caron E."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Caron E."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Hartwieg E."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/author | "Hartwieg E."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/pages | "477-489"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/pages | "477-489"xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/title | "The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/title | "The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/11703939 | http://purl.uniprot.org/core/volume | "1"xsd:string |