| http://purl.uniprot.org/citations/11705748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11705748 | http://www.w3.org/2000/01/rdf-schema#comment | "P-selectin-dependent leukocyte-endothelial cell adhesion has been implicated in the pathogenesis of ischemia/reperfusion (I/R) injury in several vascular beds, including the gut. Because platelet-endothelial (P/E) cell adhesion also occurs in postischemic venules, the possibility exists that the expression of P-selectin on the surface of platelets that are adherent to venular endothelial cells may mediate the leukocyte recruitment elicited by I/R. P-selectin expression [dual radiolabeled monoclonal antibody (MAb) technique] and neutrophil accumulation [myeloperoxidase (MPO) activity] were measured in the postischemic small intestine of untreated rats and rats treated with either antiplatelet serum (APS) or MAbs directed against either P-selectin, GPIIb/IIIa, or fibrinogen. The increases in P-selectin expression and tissue MPO normally elicited by I/R were significantly attenuated in the different treatment groups, suggesting that I/R-induced neutrophil recruitment is a platelet-dependent, P-selectin-mediated process. Intravital microscopy was then employed to examine this process relative to leukocyte-endothelial cell adhesion in postischemic rat mesenteric venules. The recruitment of adherent and emigrated leukocytes after I/R was attenuated by pretreatment with a MAb against, either P-selectin, GPIIb/IIIa, or fibrinogen, as well as an Arg-Gly-Asp peptide. Whereas thrombocytopenia greatly blunted leukocyte emigration, it did not alter the leukocyte adherence response to I/R. These findings suggest that platelet-associated P-selectin contributes to the accumulation of leukocytes in postischemic tissue via a mechanism that alters transendothelial leukocyte migration."xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.2001.281.6.g1432"xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/author | "Granger D.N."xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/author | "Issekutz A.C."xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/author | "Krieglstein C.F."xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/author | "Salter J.W."xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/pages | "G1432-9"xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/title | "Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation."xsd:string |
| http://purl.uniprot.org/citations/11705748 | http://purl.uniprot.org/core/volume | "281"xsd:string |
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