| http://purl.uniprot.org/citations/11707077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11707077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11707077 | http://www.w3.org/2000/01/rdf-schema#comment | "The liver-specific protein cAMP-GEFII (also known as Epac2) belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins having guanine nucleotide exchange factor (GEF) activity (the cAMP-GEF family). Here we clone the gene EPAC2, encoding cAMP-GEFII, from a human liver cDNA library. Human EPAC2 has at least 31 exons and is mapped to human chromosome 2q31. Analyses by primer extension, reverse transcriptase-polymerase chain reaction, and in situ hybridization revealed the presence of three transcription start sites of liver-specific Epac2: two major sites located in exon 10 and a minor site in intron 9. The same translation start site is used in all three transcripts. Liver-specific cAMP-GEFII protein, which lacks the first cAMP-binding domain and the Dishevelled/Egl-10/Pleckstrin domain, was detected at 79 kDa by immunoblot analysis, confirming the presence of the short form of cAMP-GEFII in the liver. Liver-specific cAMP-GEFII also has GEF activity toward Rap1. These results demonstrate the presence of liver-specific cAMP-GEFII. Together with the previous finding that cAMP-GEFII is responsible for cAMP-dependent exocytosis in secretory cells, our study suggests that cAMP-GEFII may have a distinct role in liver."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.2001.6641"xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.2001.6641"xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Ueno H."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Ueno H."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Ozaki N."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Ozaki N."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Matsukura S."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Matsukura S."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Seino S."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Seino S."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Yokoi N."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Yokoi N."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Liu L.M."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Liu L.M."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Iwanaga T."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Iwanaga T."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Yano H."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Yano H."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Yokoyama Y."xsd:string |
| http://purl.uniprot.org/citations/11707077 | http://purl.uniprot.org/core/author | "Yokoyama Y."xsd:string |