| http://purl.uniprot.org/citations/11707405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11707405 | http://www.w3.org/2000/01/rdf-schema#comment | "ShcA and Grb2 are crucial components in signalling by most tyrosine kinase-associated receptors. How ever, it is not clear whether Grb2 bound directly to the receptor is equivalent to Grb2 associated via ShcA. We have used signalling stimulated by the middle T-antigen (MT) of polyoma virus to address this question. The two known Grb2-binding sites from murine ShcA, 313Y and 239/240YY, could functionally replace the MT ShcA-interacting region in transformation assays using Rat2 fibroblasts. This demonstrates that signal output from membrane-bound ShcA requires only these two sequences and the ShcA-binding site in MT does not recruit other signalling molecules. Two standard Grb2-interacting sequences, either from the EGF receptor or the ShcA 313Y region, could not replace the requirement for ShcA binding to MT, indicating an enhanced role for the ShcA 239/240YY motif. Sos1 and the docking protein Gab1 are brought into the MT complex through Grb2 association and this may be more effective using the 239/240YY sequence."xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.22.6337"xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/author | "Dilworth S.M."xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/author | "Nicholson P.R."xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/author | "Empereur S."xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/author | "Glover H.R."xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/pages | "6337-6346"xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/title | "ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen."xsd:string |
| http://purl.uniprot.org/citations/11707405 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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| http://purl.uniprot.org/citations/11707405 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11707405 |
| http://purl.uniprot.org/uniprot/#_P21583-mappedCitation-11707405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11707405 |
| http://purl.uniprot.org/uniprot/#_P06239-mappedCitation-11707405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11707405 |
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| http://purl.uniprot.org/uniprot/#_P12931-mappedCitation-11707405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11707405 |
| http://purl.uniprot.org/uniprot/#_Q06124-mappedCitation-11707405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11707405 |
| http://purl.uniprot.org/uniprot/#_P62993-mappedCitation-11707405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11707405 |
| http://purl.uniprot.org/uniprot/P12931 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11707405 |
| http://purl.uniprot.org/uniprot/P21583 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11707405 |