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| http://purl.uniprot.org/citations/11707492 | http://www.w3.org/2000/01/rdf-schema#comment | "As in most invertebrate microvillar photoreceptors, phototransduction in Drosophila melanogaster uses a G-protein-coupled phosphoinositide pathway, whereby hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP(2)) by phospholipase C generates inositol 1,4,5-trisphosphate (InsP(3)) and diacyl glycerol (DAG), leading to activation of two classes of Ca(2+)-permeable light-sensitive channel, encoded by the trp and trpl genes. In some invertebrate photoreceptors, excitation is mediated by release of Ca(2+) from intracellular stores by InsP(3); however, in Drosophila melanogaster, recent evidence suggests instead that a lipid messenger, such as DAG, its metabolites and/or the reduction in PIP(2) levels, may mediate excitation. Like vertebrate rods, Drosophila melanogaster photoreceptors generate quantum bumps in response to single photons, but their kinetics is approximately 10-100 times faster, and this reflects a fundamentally different strategy incorporating a threshold, positive and negative feedback by Ca(2+) acting downstream of phospholipase C and a refractory period."xsd:string |
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| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/author | "Hardie R.C."xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/author | "Hardie R.C."xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
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| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/name | "J. Exp. Biol."xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/name | "J. Exp. Biol."xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/pages | "3403-3409"xsd:string |
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| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/title | "Phototransduction in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/title | "Phototransduction in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/11707492 | http://purl.uniprot.org/core/volume | "204"xsd:string |
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