| http://purl.uniprot.org/citations/11714750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11714750 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-18 is a recently discovered cytokine that modulates both T helper type 1 (Th1) and Th2 responses. IL-18 is elevated during acute graft-versus-host disease (GVHD). We investigated the role of IL-18 in this disorder using a well characterized murine bone marrow transplantation (BMT) model (B6 --> B6D2F1). Surprisingly, blockade of IL-18 accelerated acute GVHD-related mortality. In contrast, administration of IL-18 reduced serum tumor necrosis factor (TNF)-alpha and lipopolysaccharide (LPS) levels, decreased intestinal histopathology, and resulted in significantly improved survival (75 vs. 15%, P < 0.001). Administration of IL-18 attenuated early donor T cell expansion and was associated with increased Fas expression and greater apoptosis of donor T cells. The administration of IL-18 no longer protected BMT recipients from GVHD when Fas deficient (lpr) mice were used as donors. IL-18 also lost its ability to protect against acute GVHD when interferon (IFN)-gamma knockout mice were used as donors. Together, these results demonstrate that IL-18 regulates acute GVHD by inducing enhanced Fas-mediated apoptosis of donor T cells early after BMT, and donor IFN-gamma is critical for this protective effect."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.194.10.1433"xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Reddy P."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Teshima T."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Ferrara J.L."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Kukuruga M."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Lowler K."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/author | "Ordemann R."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/pages | "1433-1440"xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/title | "Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/11714750 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11714750 |
| http://purl.uniprot.org/citations/11714750 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11714750 |
| http://purl.uniprot.org/uniprot/P70380#attribution-B046FF3B8B99A590706A76209B4E1626 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11714750 |
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| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-11714750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11714750 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-11714750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11714750 |
| http://purl.uniprot.org/uniprot/#_A0PJ18-mappedCitation-11714750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11714750 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-11714750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11714750 |