| http://purl.uniprot.org/citations/11714751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11714751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11714751 | http://www.w3.org/2000/01/rdf-schema#comment | "During an immune response naive T helper (Th) cells differentiate into two functionally distinct subsets, Th1 and Th2, based on their cytokine secretion profile and immunomodulatory function. c-Jun amino terminal kinase (JNK) regulates Th cell differentiation by activating a transcriptional program required for cytokine production. We have recently identified a TNFR superfamily death domain-containing molecule, death receptor (DR)6, which potently activates JNK. T cells from DR6-deficient mice are substantially impaired in JNK activation. When DR6(-/-) mice were challenged with protein antigen, their T cells hyperproliferate and display a profound polarization toward a Th2 response whereas Th1 differentiation is not equivalently affected. In addition, DR6(-/)-T cells showed preference toward Th2 differentiation in vitro. The phenotype seen in the DR6(-/)-mice is not due to the apoptotic pathway. Therefore, DR6, working through JNK, rather than apoptosis, functions to attenuate the Th2 response. This is the first demonstration of a role in the activation and differentiation of Th cells by DR6 in particular and DRs in general."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.194.10.1441"xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.194.10.1441"xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Erickson S."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Erickson S."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Grewal I.S."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/author | "Grewal I.S."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/pages | "1441-1448"xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/pages | "1441-1448"xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/title | "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/11714751 | http://purl.uniprot.org/core/title | "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice."xsd:string |