| http://purl.uniprot.org/citations/11714776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11714776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11714776 | http://www.w3.org/2000/01/rdf-schema#comment | "The membrane receptor 2B4 is a CD2 family member that is involved in lymphocyte activation. A fraction of human CD8+ alphabeta T cells up-regulate 2B4 in vivo, and here we demonstrate that this correlates with the acquisition of effector cell properties such as granzyme B and perforin expression, rapid IFN-gamma production, and down-regulation of the lymph node homing chemokine receptor CCR7. In PBLs from healthy donors, cytomegalovirus-specific effector T cells were 2B4 positive, whereas naive melanoma Ag (Melan-A/melanoma Ag recognized by T cells-1)-specific T cells were 2B4 negative. In melanoma patients, Melan-A-specific T cells up-regulated 2B4 in parallel with in vivo differentiation. This occurred in PBLs after vaccination with Melan-A peptides and in tumor-infiltrated lymph nodes, likely through disease-associated activation of Melan-A-specific T cells. Thus, 2B4 expression correlates with CD8+ T cell differentiation in vivo."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.11.6165"xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.11.6165"xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Romero P."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Romero P."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Ayyoub M."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Ayyoub M."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Batard P."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Batard P."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Cerottini J.C."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Cerottini J.C."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Guillaume P."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Guillaume P."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Lienard D."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Lienard D."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Pittet M.J."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Pittet M.J."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Speiser D.E."xsd:string |
| http://purl.uniprot.org/citations/11714776 | http://purl.uniprot.org/core/author | "Speiser D.E."xsd:string |