| http://purl.uniprot.org/citations/11714812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11714812 | http://www.w3.org/2000/01/rdf-schema#comment | "Several reports have indicated that cell lineages apart from NK and T cells can also express IFN-gamma. However, the biological relevance of this finding is uncertain. We show in this study that bone marrow-derived macrophages (BMMs) express IFN-gamma at the mRNA and protein level early after infection with Chlamydia pneumoniae. Increased IFN-gamma mRNA accumulation by infected BMMs is early, transient, and requires both bacterial and host protein synthesis. The induction of IFN-gamma mRNA levels is independent of IL-12 and was dramatically enhanced in IL-10(-/-) BMMs. Such IL-10(-/-) BMMs contained less bacteria than the wild-type controls, whereas IFN-gammaR(-/-) BMMs showed increased C. pneumoniae load. Inducible NO synthase (iNOS) also participates in the control of bacterial load, as shown by the enhanced numbers of C. pneumoniae in iNOS(-/-) BMMs. However, the increased accumulation of iNOS mRNA and NO in C. pneumoniae-infected BMMs depended on the presence of IFN-alphabeta, but was independent of IFN-gamma. Interestingly, IFN-alphabeta are also required for increased IFN-gamma mRNA accumulation in C. pneumoniae-infected BMMs. Accordingly, IFN-alphabetaR(-/-) BMMs showed higher levels of C. pneumoniae than wild-type BMMs. Our findings unravel an autocrine/paracrine macrophage activation pathway by showing an IFN-alphabeta-dependent IFN-gamma and iNOS induction in response to infection, which protects macrophages against intracellular bacterial growth."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.11.6453"xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/author | "Wigzell H."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/author | "Andersson U."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/author | "Palmblad K."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/author | "Rottenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/author | "Gigliotti D."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/author | "Rothfuchs A.G."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/pages | "6453-6461"xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/title | "IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection."xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/11714812 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11714812 |
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