| http://purl.uniprot.org/citations/11716477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11716477 | http://www.w3.org/2000/01/rdf-schema#comment | "The human serotonin-4 (5-HT(4)) receptor gene expression is highly regulated in various tissues. We isolated the human 5-HT(4) receptor gene containing the 5'-flanking region and characterized its promoter. By 5'-RACE (5'-rapid amplification of the cDNA ends) and inverse PCR, multiple transcription initiation sites were identified. The most 5' one (assigned to +1) was 5135 bp upstream to the translation start site. The 500-bp 5'-flanking region contained potential binding sites for transcription factor Sp-1, AP-2, AP-4, and GATA. However, this region lacked TATA- and CAAT-boxes. Transient transfection analyses in human choriocarcinoma T3M-3 (5-HT(4) receptor-positive) and HepG2 (5-HT(4) receptor-negative) cells revealed that the region (-210 to -105) is necessary for the basic and cell-type specific 5-HT(4) receptor gene expression. In addition, untranslated exon 1 contained negative (+112 to +182) as well as positive (+1 to +111) modulators, indicating that exon 1 plays a regulatory role in the 5-HT(4) receptor gene expression."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.5979"xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Matsui H."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Okawa Y."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Ino M."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Hiroi T."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Aoba A."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Nagumo S."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/author | "Hayashi-Kobayashi N."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/pages | "337-344"xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/title | "Identification and characterization of the human serotonin-4 receptor gene promoter."xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/11716477 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11716477 |
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