| http://purl.uniprot.org/citations/11716531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11716531 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we analyzed the response of DX5+ NK and NK T cells to in vitro stimulation with IL-12 or IL-18. Production of IFN-gamma in response to either IL-12 or IL-18 was dependent upon costimulation with either IL-2 or IL-15. DX5+ splenocytes showed a rapid (6 h) and sustained (6-72 h) accumulation of IFN-gamma transcripts followed by a delayed (12-24 h) up-regulation of IL-10 or IL-13 expression in response to IL-2 + IL-12 or IL-2 + IL-18, respectively. Incubation of DX5+ splenocytes with the combination of IL-2 + IL-12 + IL-18 resulted in up-regulation of IFN-gamma and IL-13 transcripts but down-regulation of IL-10 expression. Furthermore, two distinct populations of cells producing differing amounts of IFN-gamma were observed by intracellular staining after stimulation with IL-2 + IL-12 + IL-18. Last, we demonstrate that DX5+ cells respond to IL-18 independently of IL-12, as cells from both wild-type and IL-12Rbeta2KO mice produce IFN-gamma and IL-13 in response to IL-2 + IL-18."xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.org/dc/terms/identifier | "doi:10.1006/cimm.2001.1844"xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/author | "Webb J.R."xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/author | "Lemay A.M."xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/author | "Chakir H."xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/pages | "71-81"xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/title | "Cytokine expression by murine DX5+ cells in response to IL-12, IL-18, or the combination of IL-12 and IL-18."xsd:string |
| http://purl.uniprot.org/citations/11716531 | http://purl.uniprot.org/core/volume | "212"xsd:string |
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