| http://purl.uniprot.org/citations/11716769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11716769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11716769 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutamine:fructose-6-phosphate aminotransferase (GFAT; EC 2.6.1.16) expression is tightly regulated in the context of amino sugar synthesis in many organisms from yeast to humans by transcriptional and post-translational processes. We have cloned the cDNA of the GFAT1 of Drosophila melanogaster (Dmel/Gfat1). One of the two putative protein kinase A (PKA) phosphorylation sites proposed for the regulation of human GFAT1 [Zhou, Huynh, Hoffmann, Crook, Daniels, Gulve and McClain (1998) Diabetes 47, 1836-1840] is conserved in Dmel/GFAT1. In the other one the reactive serine has been converted to a cysteine, making further access by PKA unlikely. The Dmel/Gfat1 gene is localized at position 81F on the right arm of chromosome 3. By whole-mount in situ hybridization specific expression of Dmel/GFAT1 was detected in embryonic chitin-synthesizing tissues and in the corpus cells of salivary glands from late third larval instar. Expressing Dmel/GFAT1 in yeast we showed that Dmel/GFAT1 activity is controlled by UDP-N-acetylglucosamine and PKA in the yeast total protein extract system. We propose a model for the independent regulation of the Dmel/GFAT1 enzyme by feedback inhibition and PKA."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.org/dc/terms/identifier | "doi:10.1042/0264-6021:3600401"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.org/dc/terms/identifier | "doi:10.1042/0264-6021:3600401"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/author | "Kress H."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/author | "Kress H."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/author | "Graack H.R."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/author | "Graack H.R."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/author | "Cinque U."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/author | "Cinque U."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/pages | "401-412"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/pages | "401-412"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/title | "Functional regulation of glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1) of Drosophila melanogaster in a UDP-N-acetylglucosamine and cAMP-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/title | "Functional regulation of glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1) of Drosophila melanogaster in a UDP-N-acetylglucosamine and cAMP-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/11716769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11716769 |
| http://purl.uniprot.org/citations/11716769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11716769 |
| http://purl.uniprot.org/citations/11716769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11716769 |
| http://purl.uniprot.org/citations/11716769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11716769 |