| http://purl.uniprot.org/citations/11717497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11717497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11717497 | http://www.w3.org/2000/01/rdf-schema#comment | "Grancalcin is a cytosolic Ca(2+)-binding protein originally identified in human neutrophils. It belongs to a new class of EF-hand proteins, called PEF proteins, which contain five EF-hand motifs. At the N-terminus of grancalcin there is a approximately 50 residue-long segment rich in glycines and prolines. The fifth EF-hand, unpaired within the monomer, provides a means for dimerization through pairing with its counterpart in a second molecule. The structure of full-length grancalcin in the apo form and with one EF3 within the dimer occupied by a Ca(2+) ion have been determined. Although the N-terminal segment was present in the molecule, this part was disordered in the crystals. Here, the structure of a truncated form of grancalcin, which is lacking 52 N-terminal residues, in the presence and absence of Ca(2+) is presented. In the Ca(2+)-bound form the ions are found in the EF1 and EF3 hands. Binding of Ca(2+) to these two EF hands produces only minor conformational changes, mostly within the EF1 Ca(2+)-binding loop. This observation supports the hypothesis, formulated on the basis of the structure of a homologous protein ALG-2 which shows significant differences in the orientation of EF4 and EF5 compared with grancalcin, that calcium is a necessary factor but not sufficient alone for inducing a significant conformational change in PEF proteins."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444901016511"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444901016511"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Cygler M."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Cygler M."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Borregaard N."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Borregaard N."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Lollike K."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/author | "Lollike K."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/name | "Acta Crystallogr. D"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/pages | "1843-1849"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/pages | "1843-1849"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/title | "Structure of Ca(2+)-loaded human grancalcin."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/title | "Structure of Ca(2+)-loaded human grancalcin."xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/11717497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11717497 |
| http://purl.uniprot.org/citations/11717497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11717497 |