| http://purl.uniprot.org/citations/11719458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11719458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11719458 | http://www.w3.org/2000/01/rdf-schema#comment | "A recently identified ribonucleotide reductase (RR), p53R2, is directly regulated by p53 for supplying nucleotides to repair damaged DNA. We examined the role of this p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint, comparing it to R2-dependent DNA synthesis. The elevation of DNA synthesis activity through RR in response to gamma-irradiation was closely correlated with the level of expression of p53R2 but not of R2. The p53R2 product accumulated in nuclei, whereas R2 levels in cytoplasm decreased. We found a point mutation of p53R2 in cancer cell line HCT116, which resulted in loss of RR activity. In those cells, DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53AIP1. The results suggest that p53R2-dependent DNA synthesis plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53-dependent apoptosis to eliminate dangerous cells."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Arakawa H."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Arakawa H."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Matsuda K."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Matsuda K."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Fujino M.A."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Fujino M.A."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Iwadate M."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Iwadate M."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Sagiya Y."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/author | "Sagiya Y."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/pages | "8256-8262"xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/pages | "8256-8262"xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/title | "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint."xsd:string |
| http://purl.uniprot.org/citations/11719458 | http://purl.uniprot.org/core/title | "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint."xsd:string |