| http://purl.uniprot.org/citations/11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11719516 | http://www.w3.org/2000/01/rdf-schema#comment | "The BRG-1 subunit of the SWI-SNF complex is involved in chromatin remodeling and has been implicated in the action of the retinoblastoma tumor suppressor (RB). Given the importance of BRG-1 in RB function, germ line BRG-1 mutations in tumorigenesis may be tantamount to RB inactivation. Therefore, in this study we assessed the behavior of cells harboring discrete BRG-1 alleles for the RB-signaling pathway. Using p16ink4a, an upstream activator of endogenous RB, or a constitutively active RB construct (PSM-RB), we determined that the majority of tumor lines with germ line defects in BRG-1 were sensitive to RB-mediated cell cycle arrest. By contrast, A427 (lung carcinoma) cells were resistant to expression of p16ink4a and PSM-RB. Analysis of the SWI-SNF subunits in the different tumor lines revealed that A427 are deficient for BRG-1 and its homologue, Brm, whereas RB-sensitive cell lines retained Brm expression. Similarly, the RB-resistant SW13 and C33A cell lines were also deficient for both BRG-1/Brm. Reintroduction of either BRG-1 or Brm into A427 or C33A cells restored RB-mediated signaling to cyclin A to cause cell cycle arrest. Consistent with this compensatory role, we observed that Brm could also drive expression of CD44. We also determined that loss of these core SWI-SNF subunits renders SW13 cells resistant to activation of the RB pathway by the chemotherapeutic agent cisplatin, since reintroduction of either BRG-1 or Brm into SW13 cells restored the cisplatin DNA-damage checkpoint. Together, these data demonstrate that Brm can compensate for BRG-1 loss as pertains to RB sensitivity."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109532200"xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Kowalik T.F."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Weissman B.E."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Knudsen E.S."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Knudsen K.E."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Angus S.P."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Betz B.L."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Gunawardena R.W."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Reisman D.N."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/author | "Strobeck M.W."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/pages | "4782-4789"xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/title | "Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling."xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11719516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11719516 |
| http://purl.uniprot.org/citations/11719516 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11719516 |
| http://purl.uniprot.org/uniprot/#_A7E2E1-mappedCitation-11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11719516 |
| http://purl.uniprot.org/uniprot/#_A5D6X0-mappedCitation-11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11719516 |
| http://purl.uniprot.org/uniprot/#_B3KNW7-mappedCitation-11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11719516 |
| http://purl.uniprot.org/uniprot/#_B4DK35-mappedCitation-11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11719516 |
| http://purl.uniprot.org/uniprot/#_B4DSI8-mappedCitation-11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11719516 |
| http://purl.uniprot.org/uniprot/#_B4DSC8-mappedCitation-11719516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11719516 |