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http://purl.uniprot.org/citations/11720865http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11720865http://www.w3.org/2000/01/rdf-schema#comment"Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.org/dc/terms/identifier"doi:10.1016/s0960-894x(01)00661-8"xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Siddiqui M.A."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Levesque S."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Rubin J.R."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Bachand B."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Edmunds J.J."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Leblond L."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"St-Denis Y."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Winocour P.D."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/author"Preville P."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/name"Bioorg Med Chem Lett"xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/pages"3161-3164"xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/title"Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues."xsd:string
http://purl.uniprot.org/citations/11720865http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/11720865http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11720865
http://purl.uniprot.org/citations/11720865http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11720865
http://purl.uniprot.org/uniprot/#_P00734-mappedCitation-11720865http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11720865
http://purl.uniprot.org/uniprot/P00734http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/11720865