| http://purl.uniprot.org/citations/11729207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11729207 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) family members, which include bone morphogenetic proteins (BMPs) and TGF-betas, elicit their cellular effects by activating specific Smad proteins, which control the transcription of target genes. BMPs and TGF-betas have overlapping as well as specific effects on mesenchymal cell differentiation for which the mechanisms are incompletely understood. Here we report that Id1, a dominant negative inhibitor of basic helix-loop-helix proteins, is a direct target gene for BMP. BMP, but not TGF-beta, strongly activates the Id1 promoter in an Smad-dependent manner. We identified two BMP-responsive regions in the mouse Id1 promoter, which contain three distinct sequence elements; one region contains two Smad binding elements (SBEs), and the other region contains a GGCGCC palindromic sequence flanked by two CAGC and two CGCC motifs. Whereas SBEs and GGCGCC sequence are critically important, the CAGC and CGCC motifs are needed for efficient BMP-induced Id1 promoter activation. Smads are part of nuclear transcription factor complexes that specifically bind to SBEs and GGCGCC sequence in response to BMP but not TGF-beta. Multimerization of the all three distinct sequence motifs is needed to generate a highly sensitive and BMP/Smad-dependent specific enhancer. Our results provide important new insights into how the BMP/Smad pathway can specifically activate target genes."xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111023200"xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/author | "Korchynskyi O."xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/pages | "4883-4891"xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/title | "Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter."xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11729207 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11729207 |
| http://purl.uniprot.org/citations/11729207 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11729207 |
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| http://purl.uniprot.org/uniprot/#_Q9CRR7-mappedCitation-11729207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11729207 |
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| http://purl.uniprot.org/uniprot/P97454 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11729207 |
| http://purl.uniprot.org/uniprot/P41134 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11729207 |