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| http://purl.uniprot.org/citations/11731235 | http://www.w3.org/2000/01/rdf-schema#comment | "During brain development, Pax6 is expressed in specific regions of the diencephalon including secretory cells of the subcommissural organ (SCO), a circumventricular organ at the forebrain-midbrain boundary that originates from the pretectal dorsal midline neuroepithelial cells beneath the posterior commissure (PC). Homozygous small eye (Sey/Sey) mice lack functional Pax6 protein and fail to develop the SCO, a normal PC and the pineal gland. Small eye heterozygotes (Sey/+) show defective development of the SCO's basal processes which normally penetrate the PC, indicating that normal development of the gland requires normal Pax6 gene-dosage. A correlation between the defects of SCO formation and altered R- and OB-cadherin expression patterns in the SCO is observed in mutants suggesting a role for cadherins in SCO development."xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(01)00527-5"xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/author | "Fernandez-Llebrez P."xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/author | "Price D.J."xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/author | "Estivill-Torrus G."xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/author | "Vitalis T."xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/pages | "215-224"xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/title | "The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ."xsd:string |
| http://purl.uniprot.org/citations/11731235 | http://purl.uniprot.org/core/volume | "109"xsd:string |
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