| http://purl.uniprot.org/citations/11733138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11733138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11733138 | http://www.w3.org/2000/01/rdf-schema#comment | "TAO1 and TAO2 are recently described protein kinases whose initial characterization has placed them at the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase kinase (MEKK) level of stress-responsive MAPK pathways. Because their physiological roles have not been identified, we sought to study their C. elegans homolog to learn more about their functions. kin-18 encodes a previously uncharacterized protein in C. elegans whose catalytic domain shares over 60% identity with TAO1 and TAO2. We demonstrate that KIN-18 is a protein of 120 kDa whose promoter is active in the pharynx and intestine of C. elegans. To learn more about TAO/KIN-18 function, we studied how expression of constitutively active forms of TAO1 or KIN-18 would affect the physiology of intact worms. Strains of C. elegans expressing active forms of TAO1 or KIN-18 exhibit altered pharyngeal electrophysiology as measured by electropharyngeogram. These worms grow more slowly and lay fewer eggs, phenotypes that could result from reduced feeding. We have also identified a C. elegans gene that encodes a protein kinase similar to mammalian MAPK/ERK Kinase (MEK) 4 whose promoter is active in the pharynx. It is phosphorylated by TAO1 in vitro and physically interacts with TAO1."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(01)00752-1"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(01)00752-1"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Avery L."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Avery L."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Cobb M.H."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Cobb M.H."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Hutchison M."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Hutchison M."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Berman K.S."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/author | "Berman K.S."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/pages | "137-147"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/pages | "137-147"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/title | "kin-18, a C. elegans protein kinase involved in feeding."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/title | "kin-18, a C. elegans protein kinase involved in feeding."xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/11733138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11733138 |
| http://purl.uniprot.org/citations/11733138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11733138 |