| http://purl.uniprot.org/citations/11733497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11733497 | http://www.w3.org/2000/01/rdf-schema#comment | "In skeletal muscle, voltage-dependent potentiation of L-type Ca(2+) channel (Ca(V)1.1) activity requires phosphorylation by cyclic AMP-dependent protein kinase (PKA) anchored via an A kinase-anchoring protein (AKAP15). However, the mechanism by which AKAP15 targets PKA to L-type Ca(2+) channels has not been elucidated. Here we report that AKAP15 directly interacts with the C-terminal domain of the alpha(1) subunit of Ca(V)1.1 via a leucine zipper (LZ) motif. Disruption of the LZ interaction effectively inhibits voltage-dependent potentiation of L-type Ca(2+) channels in skeletal muscle cells. Our results reveal a novel mechanism whereby anchoring of PKA to Ca(2+) channels via LZ interactions ensures rapid and efficient phosphorylation of Ca(2+) channels in response to local signals such as cAMP and depolarization."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109814200"xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/author | "Catterall W.A."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/author | "Scheuer T."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/author | "Ahn M."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/author | "Hauschka S.D."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/author | "Hulme J.T."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/pages | "4079-4087"xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/title | "A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function."xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11733497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11733497 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P7B3-mappedCitation-11733497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11733497 |
| http://purl.uniprot.org/uniprot/#_H3BJL8-mappedCitation-11733497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11733497 |
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| http://purl.uniprot.org/uniprot/#_Q8BVR3-mappedCitation-11733497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11733497 |
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