| http://purl.uniprot.org/citations/11733506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11733506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11733506 | http://www.w3.org/2000/01/rdf-schema#comment | "The small GTPase Rab family, which cycles between GTP-bound active and GDP-bound inactive states, plays an important role in membrane trafficking. Among them, Rab5 is involved in early endocytic pathway, and several Rab5-binding proteins have been identified as regulators or effectors to coordinate the docking and fusion processes of endocytic vesicles. We describe a novel binding protein exhibiting unique biochemical properties for Rab5. The Rab5-binding protein enhances GDP-GTP exchange reaction on Rab5 but preferentially interacts with its GTP-bound form. Gel filtration and immunoprecipitation analyses indicate that the Rab5-binding protein functions as a tetramer composed of anti-parallel linkage of two parallel dimers. These results suggest that the newly identified protein may function as an upstream activator and/or downstream effector for Rab5 in endocytic pathway. Possible roles of the quaternary structure have been discussed in terms of the Rab5-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106276200"xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106276200"xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Katada T."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Katada T."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Kontani K."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Kontani K."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Kajiho H."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Kajiho H."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Murai J."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Murai J."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Kurosu H."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/author | "Kurosu H."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/pages | "3412-3418"xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/pages | "3412-3418"xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/title | "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5."xsd:string |
| http://purl.uniprot.org/citations/11733506 | http://purl.uniprot.org/core/title | "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5."xsd:string |