| http://purl.uniprot.org/citations/11733576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11733576 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor (TNF) is a proinflammatory cytokine, which is centrally involved in several inflammatory disorders. Administration of TNF leads to a potentially lethal systemic inflammatory response syndrome (SIRS). We observed that (a) mice lacking functional genes for metallothionein 1 and 2 (MT-null) were protected compared with wild-type controls (P = 0.0078), and (b) mice overexpressing MT-1 (MT-TG) were more sensitized for the lethal effect of TNF than control mice (P = 0.0003), indicating a mediating role for MT in TNF induced SIRS. As MT is involved in the body zinc homeostasis, we tested whether zinc-deprivation or -supplementation alters the response to TNF. Although zinc-depletion strongly sensitized (P = 0.036), and pretreatment with zinc sulfate (ZnSO4) conferred protection against the deleterious effects of TNF (P < 0.0002), it was also found that the protection provided by zinc is independent of MT. Our observation that hsp70 is strongly induced in jejunum after ZnSO4 treatment, suggests a contribution of hsp70 in the protection against TNF. In addition, ZnSO4 cotreatment allowed complete regression of inoculated tumors with TNF and interferon gamma, leading to a significantly better survival (P = 0.0045)."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.194.11.1617"xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/author | "Vandekerckhove J."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/author | "Tavernier J."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/author | "Libert C."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/author | "Brouckaert P."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/author | "Broekaert D."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/author | "Waelput W."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/pages | "1617-1624"xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/title | "A mediator role for metallothionein in tumor necrosis factor-induced lethal shock."xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/11733576 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11733576 |
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