| http://purl.uniprot.org/citations/11734557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11734557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11734557 | http://www.w3.org/2000/01/rdf-schema#comment | "A global transcriptional co-activator, the SNF/SWI complex, has been characterized as a chromatin remodeling factor that enhances accessibility of the transcriptional machinery to DNA within a repressive chromatin structure. On the other hand, mutations in some human SNF/SWI complex components have been linked to tumor formation. We show here that SYT, a partner protein generating the synovial sarcoma fusion protein SYT-SSX, associates with native human SNF/SWI complexes. The SYT protein has a unique QPGY domain, which is also present in the largest subunits, p250 and the newly identified homolog p250R, of the corresponding SNF/SWI complexes. The C-terminal region (amino acids 310-387) of SSX1, comprising the SSX1 portion of the SYT-SSX1 fusion protein, binds strongly to core histones and oligonucleosomes in vitro and directs nuclear localization of a green fluorescence protein fusion protein. Experiments with serial C-terminal deletion mutants of SSX1 indicate that these properties map to a common region and also correlate with the previously demonstrated anchorage-independent colony formation activity of SYT-SSX in Rat 3Y1 cells. These data suggest that SYT-SSX interferes with the function of either the SNF/SWI complexes or another SYT-interacting co-activator, p300, by changing their targeted localization or by directly inhibiting their chromatin remodeling activities."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108702200"xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108702200"xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Sugano S."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Sugano S."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Krutchinsky A.N."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Krutchinsky A.N."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "de Bruijn D.R."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "de Bruijn D.R."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "An W."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "An W."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Ohtsuki Y."xsd:string |
| http://purl.uniprot.org/citations/11734557 | http://purl.uniprot.org/core/author | "Ohtsuki Y."xsd:string |