| http://purl.uniprot.org/citations/11734559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11734559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11734559 | http://www.w3.org/2000/01/rdf-schema#comment | "Receptor-interacting protein (RIP), a Ser/Thr kinase component of the tumor necrosis factor (TNF) receptor-1 signaling complex, mediates activation of the nuclear factor kappaB (NF-kappaB) pathway. RIP2 and RIP3 are related kinases that share extensive sequence homology with the kinase domain of RIP. Unlike RIP, which has a C-terminal death domain, and RIP2, which has a C-terminal caspase activation and recruitment domain, RIP3 possesses a unique C terminus. RIP3 binds RIP through this unique C-terminal segment to inhibit RIP- and TNF receptor-1-mediated NF-kappaB activation. We have identified a unique homotypic interaction motif at the C terminus of both RIP and RIP3 that is required for their association. Sixty-four amino acids within RIP3 and 88 residues within RIP are sufficient for interaction of the two proteins. This interaction is a prerequisite for RIP3-mediated phosphorylation of RIP and subsequent attenuation of TNF-induced NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109488200"xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109488200"xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Fairbrother W.J."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Fairbrother W.J."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Starovasnik M.A."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/author | "Starovasnik M.A."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/pages | "9505-9511"xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/pages | "9505-9511"xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/title | "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/title | "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11734559 | http://purl.uniprot.org/core/volume | "277"xsd:string |