| http://purl.uniprot.org/citations/11735112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11735112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11735112 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-8 is a key initiator of death receptor-induced apoptosis. Here we provide evidence that caspase-8 expression is subject to posttranscriptional regulation in human leukocytes. Resting peripheral blood lymphocytes preferentially use a distant splice donor site at the 3'-end of caspase-8 exon 8 to generate mRNAs with a truncated open reading frame. When lymphocytes were activated, the expression of caspase-8 variants was shifted to caspase-8/a and b which lack the extension of exon 8. The opposite change of the splicing pattern was found in a neutrophil differentiation model. Promyelocytic HL-60 cells mainly expressed caspase-8 mRNAs with the normal exon 8, but the splicing pattern was changed to the distant exon 8 splice site during DMSO-induced differentiation of HL-60 cells. In spite of the presence of these novel mRNAs, the corresponding translation products were not detectable in either cell type. Our findings suggest that leukocyte differentiation and alternative splicing of caspase-8 pre-mRNA are inter-dependent processes."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.6055"xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.6055"xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Fischer H."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Fischer H."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Schmitz I."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Schmitz I."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Krammer P.H."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Krammer P.H."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Krueger A."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Krueger A."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Henry M."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Henry M."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Ban J."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Ban J."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Mollinedo F."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Mollinedo F."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Eckhart L."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Eckhart L."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Tschachler E."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Tschachler E."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Bach J."xsd:string |
| http://purl.uniprot.org/citations/11735112 | http://purl.uniprot.org/core/author | "Bach J."xsd:string |