| http://purl.uniprot.org/citations/11739729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11739729 | http://www.w3.org/2000/01/rdf-schema#comment | "Free beta-tubulin not in heterodimers with alpha-tubulin can be toxic, disrupting microtubule assembly and function. We are interested in the mechanisms by which cells protect themselves from free beta-tubulin. This study focused specifically on the function of Rbl2p, which, like alpha-tubulin, can rescue cells from free beta-tubulin. In vitro studies of the mammalian homolog of Rbl2p, cofactor A, have suggested that Rbl2p/cofactor A may be involved in tubulin folding. Here we show that Rbl2p becomes essential in cells containing a modest excess of beta-tubulin relative to alpha-tubulin. However, this essential activity of Rbl2p/cofactorA does not depend upon the reactions described by the in vitro assay. Rescue of beta-tubulin toxicity requires a minimal but substoichiometric ratio of Rbl2p to beta-tubulin. The data suggest that Rbl2p binds transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic."xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.1.138-147.2002"xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/author | "Solomon F."xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/author | "Abruzzi K.C."xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/pages | "138-147"xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/title | "Protection from free beta-tubulin by the beta-tubulin binding protein Rbl2p."xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/11739729 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11739729 |
| http://purl.uniprot.org/citations/11739729 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11739729 |
| http://purl.uniprot.org/uniprot/P48606#attribution-ABD2AA7C6D17FC98CE0E8C1F7B9C1BD2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11739729 |
| http://purl.uniprot.org/uniprot/P48606#attribution-BA723F32F00EAAA79323B1A7379A4D26 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11739729 |
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| http://purl.uniprot.org/uniprot/#_P09734-mappedCitation-11739729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11739729 |
| http://purl.uniprot.org/uniprot/#_P48606-mappedCitation-11739729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11739729 |
| http://purl.uniprot.org/uniprot/P48606 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11739729 |
| http://purl.uniprot.org/uniprot/P09734 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11739729 |
| http://purl.uniprot.org/uniprot/P02557 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11739729 |
| http://purl.uniprot.org/uniprot/P40987 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11739729 |