| http://purl.uniprot.org/citations/11741535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11741535 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Cbl protooncogene is a negative regulator for several receptor tyrosine kinases (RTKs) through its ability to promote their polyubiquitination. Hence, uncoupling c-Cbl from RTKs may lead to their deregulation. In testing this, we show that c-Cbl promotes ubiquitination of the Met RTK. This requires the c-Cbl tyrosine kinase binding (TKB) domain and a juxtamembrane tyrosine residue on Met. This tyrosine provides a direct binding site for the c-Cbl TKB domain, and is absent in the rearranged oncogenic Tpr-Met variant. A Met receptor, where the juxtamembrane tyrosine is replaced by phenylalanine, is not ubiquitinated and has transforming activity in fibroblast and epithelial cells. We propose the uncoupling of c-Cbl from RTKs as a mechanism contributing to their oncogenic activation."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00378-1"xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Langdon W.Y."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Band H."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Peschard P."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Lamorte L."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Naujokas M.A."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/author | "Fournier T.M."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/pages | "995-1004"xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/title | "Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein."xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11741535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11741535 |
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