| http://purl.uniprot.org/citations/11741539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11741539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11741539 | http://www.w3.org/2000/01/rdf-schema#comment | "The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells. Here we report the reconstitution of active human Arp2/3 complex after expression of all seven subunits in insect cells. Expression of partial complexes revealed that a heterodimer of the p34 and p20 subunits constitutes a critical structural core of the complex, whereas the remaining subunits are peripherally located. Arp3 is crucial for nucleation, consistent with it being a structural component of the nucleation site. p41, p21, and p16 contribute differently to nucleation and stimulation by ActA and WASP, whereas p34/p20 bind actin filaments and likely function in actin branching. This study reveals that the nucleating and organizing functions of Arp2/3 complex subunits are separable, indicating that these activities may be differentially regulated in cells."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00393-8"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00393-8"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Welch M.D."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Welch M.D."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Goley E.D."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Goley E.D."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Niederstrasser H."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Niederstrasser H."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Gournier H."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Gournier H."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Trinh T."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/author | "Trinh T."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/pages | "1041-1052"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/pages | "1041-1052"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/title | "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/title | "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity."xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11741539 | http://purl.uniprot.org/core/volume | "8"xsd:string |